Sodium bis(trimethylsilyl)amide 双(三甲基硅基)氨基钠

规格: 2.0 M solution in THF, SpcSeal
CAS: 1070-89-9
产品编号: H12013
MDL: MFCD00009835
品牌: INFI
Chemical NameSodium bis(trimethylsilyl)amide
Synonym sodiumhexamethyldisilazane,nahmds,in SODIUM BIS(TRIMETHYLSILYL)AMIDE, ~1 M IN THF N-Sodiumhexamethyldisilazane SOD N-Sodiohe Natriumbis-(t SODIU SODIUM BIS(TRIMETHYLSILYL)AMIDE SOL., ~0 .6 M IN TOLUENE sodium-bis-(trimethylsilyl)-ami 双(三甲基硅基)胺钠 N-SODIUMHEXAMETHYLDISILAZANE sodiumhexameth {Chem HMN-Na 溶液 六甲基二硅氮烷 钠盐 溶液 NAHMDS HEXAM Sodium bis(trimethylsilyl)amide, pure, 95+% Sodium bis(trimethylsilyl)amide 六甲基二硅氮烷 钠盐 双(三甲基硅基)氨基钠 HMN NA SALT Sodium hexamethyldisilazane 双甲基硅基氨钠 双(三甲基硅基)胺钠/六甲基二硅基氮烷钠 Natrium-bis-(trimethylsilyl)-amid {u
MDL NumberMFCD00009835
CAS Number1070-89-9
EC Number213-983-8
Beilstein Registry Number3629917
PubChem Substance ID2724254
Reaxys-RN3629917
Chemical Name Translation双(三甲基硅基)氨基钠
InChIKeyWRIKHQLVHPKCJU-UHFFFAOYSA-N
InChIInChI=1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
GHS Symbol
Signal word
WGK Germany3
Safety Statements
  • S8 Keep container dry 保持容器干燥;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
    Risk Statements
    • R11 Highly flammable 非常易燃
    • R48/20
    • R14 Reacts violently with water 遇水会猛烈反应
    • R34 Causes burns 会导致灼伤
    • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
    • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
    • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
    • R19 May form explosive peroxides 可能生成易爆的过氧化物质
    • R14/15 Reacts violently with water, liberating extremely flammable gases 遇水剧烈反应,释放出高度可燃气体
    • R37 Irritating to respiratory system 刺激呼吸道
    • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
      Precautionary statements
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P305+P351+P338
      • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
      • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P403+P233
      • P305+P351+P338+P310
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P301+P330+P331+P310
      • P304+P340+P310
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
      • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
      • P233 Keep container tightly closed. ?保持容器密闭。
      • P308+P311
      • P241+P242+P243
      • P303+P361+P353+P310+P363
      • P405 Store locked up. 上锁保管。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
        Hazard statements
        • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
        • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
        • H302 Harmful if swallowed 吞食有害
        • H351 Suspected of causing cancer 怀疑致癌
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
        • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
        • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
        • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
        • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
          Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          Packing GroupII
          UN Number UN3096 UN2924 2924
          Storage condition Moisture Sensitive 易吸潮,密封保存。充入惰性气体,密闭保存。 Air & Moisture Sensitive 充氩保存 2-8°C
          Hazard Codes F,C
          Hazard Class3/8
        • ⑴. 常温下为微黄色至浅灰色结晶粉末,一般溶于四氢呋喃溶液中。
        • ⑵. 与铑(I)催化共同作用可显著加快苯乙炔的聚合反应。
        • ⑶.又称双(三甲基癸基)氨化钠
        • Significantly accelerated the polymerization of pheneylacetylene in conjunction with rhodium (I) catalysis
        • {ALF} Sufficiently nucleophilic to act as a protected form of ammonia in the synthesis of primary amines from halides and tosylates: Chem. Ber., 117, 1250 (1984).
        • {ALF} Useful sterically hindered base (NaHMDS) for, e.g. generation of enolates, Wittig reagents or carbenes.
        • {ALF} In the Wittig reaction, gives Li salt-free product distribution patterns, with selective (Z)-alkene formation: Chem. Ber., 109, 1694 (1976); Tetrahedron Lett., 30, 2173 (1989). For formation of anions of benzylic phosphonates and subsequent ɑɑ-difluorination, see N-Fluorobenzenesulfonimide, L13955.
        • {ALF} Used as a base for the preparation of ester enolates: J. Am. Chem. Soc., 93, 4945 (1971). Has been found to be superior to LDA for preparation of (Z)-enolates of ketones under thermodynamic control: Tetrahedron Lett., 30, 2779 (1989).
        • {uni_hamburg} Short: EINECS
        • {ALD} Beilstein: 4,IV,4014
        • {uni_hamburg} Short: III/35F
        • {ALF} Found to give better yields than LiHMDS or KHMDS for the carbenoid reactions with Dibromomethane, A10456: Synthesis, 201 (1972); Angew. Chem. Int. Ed., 11, 326 (1972).
        • 1070-89-9 H12013 Sodium bis(trimethylsilyl)amide
双(三甲基硅基)氨基钠

          化学属性

          Mol. FormulaC6H18NNaSi2
          Mol. Weight183.38
          Density0.87
          Melting Point171-175
          SolubilitySoluble in hexane, toluene, ether
          TSCAYes
          Flash Point-17°(1°F)
          Stability易吸潮
          Boiling Point67°C
          Density0.9197
          Mol. FormulaC6H18NNaSi2
          Mol. Weight183.38
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