多虑平

规格: 98.0%,(LC&T;)
CAS: 1229-29-4
产品编号: H60133
MDL: MFCD00079135
品牌: INFI
Chemical NameDoxepin Hydrochloride
CAS Number1229-29-4
MDL NumberMFCD00079135
Synonym 3-DIBENZ(B,C)OXEPIN 11(6H)YLIDENE-N,N-DIMETHYL-1-PROPANAMINE HYDROCHLORIDE DOXEPIN HYDROCHLORIDE cidoxepinhydrochloride 11-(3-dimethylaminopropylidene)-6,11-dihydro-benz[b,e]oxepin 1-Propanamine, 3-dibenzb,eoxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride 11-(3-dimethylaminopropylidene)-6,11-dihydro-benz[b,e]oxepin hcl 多虑平 盐酸盐 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZ[B,E]OXEPIN HYDROCHLORIDE Adapin N,N-二甲基-3-二苯并[B,E]-庚英-11(6H)亚基-丙胺盐酸盐 盐酸多塞平 3-(6,11-dihydrodibenz(b,e)oxepin-11-ylidene)propyldimethylamine hcl TIMTEC-BB SBB005916 11-dimethylaminopropylidene6h-dibenz(b,e)oxepin Doxopin hydrochloride Doxepine hydrochloride 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride 11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz(b,e)oxepin n,n-dimethyldibenz(b,e)oxepin-delta(sup11(6h),gamma)-propylaminehydrochlori N,N-二甲基-3-二苯并[b,e]-噁庚英-11(6H)亚基-丙胺盐酸盐 e)oxepin-delta(sup11(6h),gamma)-propylamine,n,n-dimethyl-dibenz(hydrochlo adapin Doxepin for system suitability p-4599 多虑平 Curatin 11-Dimethylamino propylidene 6H-dibenz(b,e)oxepin 11-(3-Dimethylaminopropylidene)-6,11-dihydro-benz[b,e]Oxepin 凯舒 Cidoxepin hydrochloride 盐酸多噻平 3-dibez[b,e]oxepin-11(6h)-ylidene-n,n-dimethyl-1-propanaminhydrochloride 11[16H]-[3-(DIMETHYLAMINO)-PROPYLIDENE]DIBENZ[B,E]OXEPINE HYDROCHLORIDE DOXEPIN HCL 盐酸多虑平 3-dibenz(b,e)oxepin-11(6h)ylidene-n,n-dimethyl-1-propanaminhydrochloride
PubChem Substance ID6419921
EC Number214-966-8
Merck Number3435
Chemical Name Translation多虑平
Wiswesser Line NotationT C676 IO&T&J B3N1&1 &GH
Reaxys-RN5463221
InChIInChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,72,1972

TYPE OF TEST            : TDLo - Lowe

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >27 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,889,1972

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,889,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1620 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,913,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 210 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   DPTHDL Developmental Pharmacology and Therapeutics.  (S. Karger Pub., Inc.,
   79 Fifth Ave., New York, NY 10003)  V.1-    1980-  Volume(issue)/page/year:
   8,17,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 45 mg/kg
SEX/DURATION            : female 8-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volu

WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
    Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
    RTECSHQ4375000
    Precautionary statements
    • P301+P310+P330
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P405 Store locked up. 上锁保管。
    • P301+P310
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      Signal word Danger
      Safety Statements
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S20 When using do not eat or drink 使用时，不得进食，饮水；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
        Hazard Codes T
        Risk Statements
        • R25 Toxic if swallowed 吞咽有毒
        • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
          Packing GroupIII
          UN Number UN 2811 6.1/PG 3 UN2811 2811
          Hazard Class6.1
          1229-29-4 H60133 多虑平

          化学属性

          Mol. FormulaC19H21NO·HCl
          Mol. Weight315.84
          TSCANo
          Melting Point186.0 to 190.0 deg-C
          Solubility1 M HCl: 50 mg/mL
          Appearance powder
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